Dr. Arif Khan at the Northwest Clinical Research Center talks about Parkinson’s disease and an exciting clinical study by Athira Pharma for the treatment of Parkinson’s Disease Dementia (PDD) and Dementia with Lewy Bodies. The medicine is designed to boost a repair and regenerative pathway for brain cells, promoting brain health and function. It’s a new approach, potentially targeting the root cause of memory decline by repairing brain cells and rebuilding brain networks. For more information, or to enroll, visit http://shapetrial.com. Dr. Khan is a Board Certified Psychiatrist, an Adjunct Professor of Psychiatry at Duke University School of Medicine and an Adjunct Professor of Clinical Medicine at the Pacific Northwest University of Health Sciences. Dr. Khan has been conducting clinical trials in the greater Seattle area since 1984 and founded the NorthWest Clinical research Center (NWCRC) in 1995. He has been the Principal Investigator in over 600 clinical trials. In addition, he has published more than 175 scientific papers in leading medical journals. His work on clinical trial design, safety and efficacy is widely recognized and presented at both national and international scientific meetings.
View Episode Transcript
*The following is the output of transcribing from an audio recording. Although the transcription is largely accurate, in some cases it is incomplete or inaccurate due to inaudible passages or transcription errors.
The following podcast is provided by an approved senior care provider on the answers for elders radio network. And welcome everyone to the answers for elders podcast network and we have been so interested in a topic and we’re going to talk to all of you out there that may know of or maybe dealing with Parkinson’s disease. Parkinson’s is really an amazing out you know SNI scenario that we have getting more and more people with inflicted with the disease and we’re really honored today to be working with a theory of Pharmaceuticals who has been we worked with a lot in dementia and Alzheimer’s research programs and clinical trial programs and amazing breakthroughs, and now we’re moving into Parkinson’s to disease, which I think is really an incredible area to discover, because a lot of us don’t may not remember and may not realize that, because Parkinson’s, again, is it is an issue with the brain. There is a very common form of dementia called Louis Body Dementia, and we’re very honored today to have Dr Khan, who is the founder of the Northwest Clinical Research Center, as sponsored by a Thera Pharma and the Dr Cohn. Welcome back to answers for elders. We talk to you a while ago about, you know, clinical research you were doing on Alzheimer’s, and now we’re moving into Parkinson’s, so I’m glad you’re here with us. Welcome. Thank you for having Dr Khan. I am wondering today, right now. I I’m interested in a statistic and I did not realize that there are currently nine hundred and Thirtyzero people in the United States living with Parkinson’s disease and it’s growing by leaps and bounds. I have heard a lot of information. Tell me a little bit of more. What is impacted that growth? Can you share with me a little bit? Yes, it’s one of the issues with aging as we get older. Uh Huh. The brain, certainly you know, has is not really as capable as it used to be. Uh Huh. The disease that you tend to see more after fifty years old. The most common one is to do with the case of Michael J Fox, right, very severe form of this way early on said, but usually it’s something you see in men after the age of fifty and essentially the brain cells all over the body are like. You know, whether you look at electrical virus or telephone virus, they all connect to each other and they have young chance and one of the junctions in the brain gets impaired in Parkinson’s disease. So you no longer can coordinate well, you become very tremulous, you’re not able to walk fast, to do things and your face sort of becomes very frozen. Right. So part of that is that’s how the outside you can tell. But one of the things that happens is that didn’t matter of kind, sometimes very early on, is that you also have trouble remembering, concentrating and able to do multiple logical steps and being able to solve problems. Yeah, for example, you go to a stop light, you can’t tell it’s a green or red, so you just freeze. So it’s a freeze kind of disease. So Parkinson’s disease when you start to get the other parts of the junction involved, that’s called the Louis Body dimension. Right. Essentially you’re not able to think, concentrate, memorize and do the normal functions one most of us are amazing, right. Yeah, and it’s something you see twice as commonly in men. Many age fifty two is the most common and the problem with this disease is that it’s can be very mortal. In other words, what happens is that you not only lose your brain functions and, more time, functions, you become so impaired that you can’t breathe well and you can’t move your muscles well. So you get bacterial and other kinds of infections and come down with pneumonia, and that’s why. So anything you can do to improve the situation, to improve the no conduction, to be able to restore function right critical. So No, it’s interesting because I’ve heard people in the past say, you know, I probably had the disease ten years before I was actually diagnosed. Did you find that that’s common with those of suffer from parkinsys disease? They may have had some signs, early symptoms that they didn’t equate to. That is, have you found that in the past? Yes, it’s very common that people, you know, think that’s it just part of aging. You don’t realize that they become more tremulous or forgetful. They just thinking as part of a normal aging process. So if you have any doubts about that you know you should see a doctor or come and see us. Be Happy to see you. Yeah, and evaluate see if you actually have a bikings disease or the dementia associated with it. Right. You know, any of the research that’s being done going to be helpful to your individual case. So what are some of the early symptoms of Parkinson’s disease? Early is these tremor. You know that they you you’ll be your hands start to shake and it’s go shaking and it’s not like fine, my young people have but it’s a more gross tremor and also you feel like it’s like, you know, car starting. You know it doesn’t start right away. It’s like the old crank shaft cars. I know, if you may get too young to remember those, there were cars that you couldn’t Bene to the key. You’re to actually more a shaft. So that’s how become. People become frozen until in the morning they can get started because they come slow, they become tremulous and they become forgetful and they come to do you know, general you know choose that you get from daylight, from sleep, food. Those Qu’es are lost. So that’s right. One of the things to watch out for. Yeah, and you need this carry give us or the spouses notice it before then the person themselves. Yeah, and obviously you know. I I love your analogy when you’re talking about like starting a car, because you know, sometimes your engine turns over. I’ve heard stories of like just even to take a first step, sometimes you have to think it up through and try it a couple times. Is that? And is that it happened like in the early stages as well? Sometimes nomber is the most early a symptom, and a thinking and concentrations also very early. Simple, but certainly what we technically, what we call as greatly can easier a Canasio, I got it. But kinectically, kinetics, you know what I mean. Moving, movement becomes very hard because, like I said, it’s like the telephone wires or the electrical wires. They don’t connect. The wires don’t connect, so you just have trouble getting started being able to do things. Yeah, I think this to and tend to, you know, walk slowly and takes a while to you know, your reflect us are not as fast as they could be. So, Dr Cohn, obviously you your your clinic is the Northwest Clinical Research Center. And you are, on behalf of a term farmer, actually conducting a clinical trial. Would you tell us a little bit about that? Yeah, the standard treatment for Parkinson’s disease is what’s called dopemine dopamine. You know, y’ll dope is what is it ministered? Uh Huh. Problem with the Yelpe. I help with some of the moment kind of things, but it does not help with the brain, you know, functions that like memory, concentration, being able to process information. So that that that sort of dementia, what becoll Louis Bardy dementia continues. The Yell Dope Dopamine kind of medications don’t have effects. So we’re looking at alternatives. So I thea a farmer, is looking at alternative. Essentially it’s a medication that really makes the set no cells go on new connections, because remember I told you the telephone wires, the connections and watched. Yeah, you want to get new connections. Yeah, this medication is about going to just amazing. Yeah. Yeah, and so obviously we are looking for individuals that have been diagnosed with, obviously Parkinson’s, who have the is it the beginning stages of Louis to Buddy Tomnia. Where we’re what is an I ideal candidate for this trial. Ideal candidate meaning that I mean it’s not something I wish. Somebody has it. That you’re absolutely but certainly you know, fifty five, sixty, sixty five year old men, okay, well, to them have you know, the develop this disease and that’s like who the One? Twice as many men have it as women. Wow, on in your s and it chardens your lifespan by ten to twenty years. So that’s why it’s very critical to through the quality of life and for along life and right all the things that go with it right, right, and obviously to to do this trial. I know there’s some really cool things about it. On, you know, you’re even doing driving people to re eve treatment. There’s different things going on with that. Tell us a little bit about what this trial is about. You know what is the medication is essentially an injection you give yourself favorite day, okay, an injection. It’s a small injection you can administer, you know, abdominal wall or on your limbs, okay, and it’s supposed to work for, you know, a whole day. Wow, will be happy to have bisons, you know, come in, we can owne transportation. We need the caregivers to come along with them so that we monitored them for safety. We do a lot of testing before and after and you’re very happy to see patients. We can get an appointment same day or the next day. Don’t want to evaluate it well where you know, I am so in awe of the Thera Farma because you guys and they work with so many amazing individuals like you, Dr Khan, about so many breakthroughs that are happening through medical trials and the the technology and the ability that we have right here in the greater puget sound area, just with our biotech sector and and having the individuals like you, Dr Con that can help make lives better for those that are suffering from brain, you know, related situations, and certainly to go to the clinical trial. We’re very excited, Dr Cohn, I’m going to give the website out and I want to make sure that all of our listeners know if you know of somebody that has Parkinson’s disease, that are here in greater puget sound that maybe suffering from Louis Body dementia, we want to hear from you and you can certainly do that through www dot shape trial, dot calm. That’s shape tar I alcom for more information and again, transportation is provided all different types of, you know, an amazing new approach to treat Parkinson’s disease, and we’re also you know, you would be the person that would be a part of really new, innovative technologies to, you know, to help your brain function better. And, of course, working with Dr Cohn and all the breakthroughs that you guys have been doing is amazing and I’m so honored to bring this in the forefront of our community. Dr Kind, thank you so much for being on the show today. We at answers for elders. Thank you for listening. Did you know that you can discover hundreds of podcasts in our library on senior care? So visit our website and discover our decision guys. That will help you also navigate decision making. Find us at answers for elders. Docom
No post found!
Originally published December 10, 2021